Ceftriaxone reducesL-dopa-induced dyskinesia severity in 6-hydroxydopamine parkinson's disease model
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چکیده
منابع مشابه
The Role of the Subthalamic Nucleus in L-DOPA Induced Dyskinesia in 6-Hydroxydopamine Lesioned Rats
L-DOPA is the most effective treatment for Parkinson's disease (PD), but prolonged use leads to disabling motor complications including dyskinesia. Strong evidence supports a role of the subthalamic nucleus (STN) in the pathophysiology of PD whereas its role in dyskinesia is a matter of controversy. Here, we investigated the involvement of STN in dyskinesia, using single-unit extracellular reco...
متن کاملUnilateral nigrostriatal 6-hydroxydopamine lesions in mice II: predicting l-DOPA-induced dyskinesia.
In the 6-hydroxydopamine (6-OHDA) lesioned rodent the location of the lesion produces significantly different behavioural phenotypes, responses to the dopamine precursor l-3,4-dihydroxyphenylalanine (l-DOPA) and neuropathology. Lesion extent is commonly determined by a series of motor tests, but whether any of these tests have a relationship to the development and predictability of dyskinesia i...
متن کاملExercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice.
L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with L-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possi...
متن کاملTargeting the D1-N-methyl-d-aspartate receptor complex reduces l-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats
L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective therapy for Parkinson's disease (PD), but its long-term administration is associated with the development of debilitating motor complications known as L-dopa-induced dyskinesia (LID). Enhanced function of dopamine D1 receptor (D1R) and N-methyl-D-aspartate receptor (NMDAR) is believed to participate in the pathogenesis of LID. Giv...
متن کاملBehavioral and Cellular Modulation of L-DOPA-Induced Dyskinesia by -Adrenoceptor Blockade in the 6-Hydroxydopamine-Lesioned Rat
Chronic dopamine replacement therapy in Parkinson’s disease (PD) leads to deleterious motor sequelae known as L-DOPAinduced dyskinesia (LID). No known therapeutic can eliminate LID, but preliminary evidence suggests that dl-1-isopropylamino-3-(1-naphthyloxy)-2-propanol [( )propranolol], a nonselective -adrenergic receptor ( AR) antagonist, may reduce LID. The present study used the rat unilater...
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ژورنال
عنوان ژورنال: Movement Disorders
سال: 2017
ISSN: 0885-3185
DOI: 10.1002/mds.27077